Clinical and laboratory aspects of condylomata lata lesions of syphilis

JM Towns; I Denham; EPF Chow; S Graves; CK Fairley; D Williamson; F Azzato; MY Chen

Journal article

Clinical and laboratory aspects of condylomata lata lesions of syphilis

JM Towns, I Denham, EPF Chow, S Graves, CK Fairley, D Williamson, F Azzato, MY Chen

Sexually Transmitted Infections | BMJ PUBLISHING GROUP | Published : 2023

DOI: 10.1136/sextrans-2021-055385

Abstract

Objectives Condylomata lata are a less common but distinctive syphilitic lesion. Variable theories as to their nature and origin exist. The aim of this study was to determine the clinical and laboratory characteristics of condylomata lata by determining (1): the most closely aligned stage of syphilis, based on the rapid plasma reagin (RPR) titre; (2) symptom duration and (3) Treponema pallidum PCR cycle threshold (C T) values, as an indicator of organism load. Methods This was a retrospective study of patients with T. pallidum PCR-positive condylomata lata lesions, attending a clinic in Melbourne, Australia, between 2011 and 2021. Syphilis serology was undertaken and RPR titres compared betw..

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University of Melbourne Researchers

Eric Chow Author

Deborah Williamson Author

Related Projects (1)

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by the Australian National Health and Medical Research Council (NHMRC) Partnership Project Grant (APP2003399). EPFC is supported by an NHMRC Emerging Leadership Investigator Grant (GNT1172873). DW is supported by an NHMRC Investigator Grant (APP1174555). JMT is supported by a Monash University post--doctoral fellowship bridging grant.